Parkinson’s disease (PD) is a progressive brain disorder that causes unintended or uncontrollable movements, such as shaking, stiffness, and difficulty with balance and coordination. It has become the second most common neurodegenerative disease in the world. While the mechanism of the onset of Parkinson’s disease remains unclear, studies have shown that Parkinson’s disease is related to genetic factors, Preclinical CRO mitochondrial dysfunction, ubiquitin-proteasome system dysfunction, and excitotoxicity. GemPharmatech has developed B6-hSNCA A53T and B6-Tfam-flox/Slc6a3-Cre models to study the mechanism of abnormal α-synuclein aggregation and mitochondrial dysfunction, respectively. These models can be…
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